|
KMID : 0603820170230030166
|
|
Journal of Experimental & Biomedical Science
2017 Volume.23 No. 3 p.166 ~ p.174
|
|
|
Targeting the Gut Microbiome to Ameliorate Cardiovascular Disease
|
|
Hwang Soon-Jae
Park Chan-Oh
Rhee Ki-Jong
|
|
|
Abstract
|
|
|
|
The bacterial cells located within the gastrointestinal tract (GIT) outnumber the host's cells by a factor of ten. These human digestive-tract microbes are referred to as the gut microbiota. During the last ten years, our understanding of gut microbiota composition and its relation with intra- and extra-intestinal diseases including risk factors of cardiovascular diseases (CVD) such as atherosclerosis and metabolic syndrome, have greatly increased. A question which frequently arises in the research community is whether one can modulate the gut microbial environment to 'control' risk factors in CVD. In this review, we summarized promising intervention methods, based on our current knowledge of intestinal microbiota in modulating CVD. Furthermore, we explore how gut microbiota can be therapeutically exploited by targeting their metabolic program to control pathologic factors of CVD.
|
|
|
KEYWORD
|
|
|
Gut microbiome , Cardiovascular diseases , Atherosclerosis , Metabolic syndrome
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|